Respiratory muscle injury, fatigue and serum skeletal troponin I in rat

Qualification of Muscle Injury Panel 2 and Rat Skeletal Troponin I Markers for Preclinical Studies

Serum skeletal troponin I in inflammatory muscle disease: relation to creatine kinase, CKMB and cardiac troponin I.

The measurement of serum creatine kinase (CK), which is used widely in the diagnosis and management of polymyositis and dermatomyositis lacks both sensitivity and specificity, leading to potential problems if the serum total CK concentration is interpreted as a direct measure of muscle disease activity. Furthermore, in those cases where the total CK is raised reliance on an analysis of the CK i...

Differential detection of skeletal troponin I isoforms in serum of a patient with rhabdomyolysis: markers of muscle injury?

in Serum of a Patient with Rhabdomyolysis: Markers of Muscle Injury? Jeremy A. Simpson, Ralf Labugger, Geoffrey G. Hesketh, Christine D’Arsigny, Denis O’Donnell, Nobuko Matsumoto, Christine P. Collier, Steve Iscoe, and Jennifer E. Van Eyk (Departments of 1 Physiology, 2 Pathology, 3 Respirology, and 4 Biochemistry, Queen’s University, and 5 Kingston General Hospital, Kingston, Ontario, K7L 3N6 ...

Colchicine protects rat skeletal muscle from ischemia/reperfusion injury by suppressing oxidative stress and inflammation

Objective(s): Neutrophils play an important role in ischemia/reperfusion (IR) induced skeletal muscle injury. Microtubules are required for neutrophil activation in response to various stimuli. This study aimed to investigate the effects of colchicine, a microtubule-disrupting agent, on skeletal muscle IR injury in a rat hindlimb ischemia model. Materials and Methods: Twenty-one Sprague-Dawley ...

Fast and slow skeletal troponin I in serum from patients with various skeletal muscle disorders: a pilot study.

BACKGROUND Detection of skeletal muscle injury is hampered by a lack of commercially available assays for serum markers specific for skeletal muscle; serum concentrations of skeletal troponin I (sTnI) could meet this need. Moreover, because sTnI exists in 2 isoforms, slow (ssTnI) and fast (fsTnI), corresponding to slow- and fast-twitch muscles, respectively, it could provide insight into differ...